"Pachyderm" was originally developed by the San Francisco Museum of Modern Art (SFMOMA) to create a tool that museum curators (non-technical people) could use to easily build engaging web, CD-ROM, and kiosk exhibits built upon the digitized assets in the museum's database. Pachyderm projects are created via a web interface, a collection of pre-built interaction templates and are presented as Flash format. SFMOMA have created an impressive number of examples.
The part I love the most is that it is all authored within a browser. The open source application is server-side. This is huge because in the world of Learning2.0 we are ALL creators of learning content and participants in the process NOT simply consumers.
Watch this presentation about Pachyderm2.0 (20mins). It tells the story better than I can.